Reaction Details Report a problem with these data
Target
Sequestosome-1
Ligand
BDBM50588581
Substrate
n/a
Meas. Tech.
ChEMBL_2187795 (CHEMBL5099877)
Kd
1490±n/a nM
Citation
 Wang, FC; Peng, B; Ren, TT; Liu, SP; Du, JR; Chen, ZH; Zhang, TT; Gu, X; Li, M; Cao, SL; Xu, X A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62. J Med Chem 65:15028-15047 (2022) [PubMed] 
Target
Name:
Sequestosome-1
Synonyms:
EBI3-associated protein of 60 kDa | EBIAP | ORCA | OSIL | Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa | SQSTM1 | SQSTM_HUMAN | Ubiquitin-binding protein p62 | p60
Type:
PROTEIN
Mol. Mass.:
47672.06
Organism:
Homo sapiens
Description:
ChEMBL_118061
Residue:
440
Sequence:
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
  
Inhibitor
Name:
BDBM50588581
Synonyms:
CHEMBL5183436
Type:
Small organic molecule
Emp. Form.:
C19H19N7O3
Mol. Mass.:
393.3993
SMILES:
COc1cc(cc(OC)c1OC)-n1cc(nn1)-c1ccc2nc(N)nc(N)c2c1
Structure:
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