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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50246040
Substrate
n/a
Meas. Tech.
ChEMBL_2187907 (CHEMBL5099989)
Ki
631±n/a nM
Citation
 Tian, Y; Shehata, MA; Gauger, SJ; Veronesi, C; Hamborg, L; Thiesen, L; Bruus-Jensen, J; Royssen, JS; Leurs, U; Larsen, ASG; Krall, J; Solbak, SMØ; Wellendorph, P; Frølund, B Exploring the NCS-382 Scaffold for CaMKII? Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII? Hub Domain. J Med Chem 65:15066-15084 (2022) [PubMed] 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CaM Kinase II | Calcium/calmodulin-dependent protein kinase type II, rat brain | Camk2a | KCC2A_RAT | calcium/calmodulin-dependent protein kinase II alpha subunit
Type:
Enzyme Mixture
Mol. Mass.:
54120.65
Organism:
Rattus norvegicus (rat)
Description:
Consists of subunits of M.W. 50,000 and 58,000-60,000 in a 3:1 ratio.
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50246040
Synonyms:
(E,RS)-(6,7,8,9-tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylidene)acetic acid | 6,7,8,9-tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid | CHEMBL472694
Type:
Small organic molecule
Emp. Form.:
C13H14O3
Mol. Mass.:
218.2485
SMILES:
OC1c2ccccc2CCC\C1=C/C(O)=O
Structure:
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