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Target
Aspartate aminotransferase, cytoplasmic
Ligand
BDBM81461
Substrate
n/a
Meas. Tech.
ChEMBL_2193281 (CHEMBL5105641)
IC50
26620±n/a nM
Citation
 Wu, Q; Sun, Z; Chen, Z; Liu, J; Ding, H; Luo, C; Wang, M; Du, D The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay. Bioorg Med Chem Lett 73:0 (2022) [PubMed] 
Target
Name:
Aspartate aminotransferase, cytoplasmic
Synonyms:
2.6.1.1 | 2.6.1.3 | AATC_HUMAN | Aspartate aminotransferase, cytoplasmic | Cysteine aminotransferase, cytoplasmic | Cysteine transaminase, cytoplasmic | GOT1 | Glutamate oxaloacetate transaminase 1 | Transaminase A | cAspAT | cCAT
Type:
PROTEIN
Mol. Mass.:
46249.45
Organism:
Homo sapiens
Description:
ChEMBL_105469
Residue:
413
Sequence:
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
  
Inhibitor
Name:
BDBM81461
Synonyms:
CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NSC_3637
Type:
Small organic molecule
Emp. Form.:
C8H8N4
Mol. Mass.:
160.1759
SMILES:
NNc1nncc2ccccc12
Structure:
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