Reaction Details Report a problem with these data
Target
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Ligand
BDBM50589383
Substrate
n/a
Meas. Tech.
ChEMBL_2193441 (CHEMBL5105801)
IC50
13480±n/a nM
Citation
 Lee, B; Gyu Kim, D; Mi Kim, Y; Kim, S; Choi, I Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors. Bioorg Med Chem Lett 73:0 (2022) [PubMed] 
Target
Name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Synonyms:
AIMP2 | AIMP2_HUMAN | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | JTV1 | JTV1 | Multisynthase complex auxiliary component p38 | Protein JTV-1
Type:
PROTEIN
Mol. Mass.:
35355.45
Organism:
Homo sapiens
Description:
ChEMBL_119035
Residue:
320
Sequence:
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK
  
Inhibitor
Name:
BDBM50589383
Synonyms:
CHEMBL5186158
Type:
Small organic molecule
Emp. Form.:
C20H18N2O3
Mol. Mass.:
334.3685
SMILES:
O=C(Cc1ccc2ncccc2c1)NCC1COc2ccccc2O1
Structure:
Search PDB for entries with ligand similarity: