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Target
Matrilysin
Ligand
BDBM50589867
Substrate
n/a
Meas. Tech.
ChEMBL_2194505 (CHEMBL5106865)
IC50
5700±n/a nM
Citation
 Tabuse, H; Abe-Sato, K; Kanazawa, H; Yashiro, M; Tamura, Y; Kamitani, M; Hitaka, K; Gunji, E; Mitani, A; Kojima, N; Oka, Y Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides. J Med Chem 65:13253-13263 (2022) [PubMed] 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50589867
Synonyms:
CHEMBL5189261
Type:
Small organic molecule
Emp. Form.:
C26H37ClF3N5O9S2
Mol. Mass.:
720.178
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CC[C@H](NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(O)=O)C(N)=O |r|
Structure:
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