Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM50589875
Substrate
n/a
Meas. Tech.
ChEMBL_2194526 (CHEMBL5106886)
IC50
230±n/a nM
Citation
 Jia, Y; Kim, RQ; Kooij, R; Ovaa, H; Sapmaz, A; Geurink, PP Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput. J Med Chem 65:13288-13304 (2022) [PubMed] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM50589875
Synonyms:
8RK64
Type:
Small organic molecule
Emp. Form.:
C14H16N8O2S
Mol. Mass.:
360.394
SMILES:
[N-]=[N+]=NCC(=O)N1CCc2nc(NC(=O)[C@H]3CCN(C3)C#N)sc2C1
Structure:
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