Reaction Details Report a problem with these data
Target
P2X purinoceptor 4
Ligand
BDBM50589922
Substrate
n/a
Meas. Tech.
ChEMBL_2194568 (CHEMBL5106928)
IC50
503±n/a nM
Citation
 Toti, KS; Verma, R; McGonnigle, MJ; Gamiotea Turro, D; Wen, Z; Lewicki, SA; Liang, BT; Jacobson, KA Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 J Med Chem 65:13967-13987 (2022) [PubMed] 
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM50589922
Synonyms:
CHEMBL5179436
Type:
Small organic molecule
Emp. Form.:
C26H28N6O3S
Mol. Mass.:
504.604
SMILES:
CCN(CC)CC.O=C1CC(=O)N(c2ccnc(c2)-c2noc(=S)[nH]2)c2ccc3ccccc3c2N1
Structure:
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