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Target
Glycogen synthase kinase 3
Ligand
BDBM50590015
Substrate
n/a
Meas. Tech.
ChEMBL_2194682 (CHEMBL5107042)
IC50
124±n/a nM
Citation
 Galal, KA; Truong, A; Kwarcinski, F; de Silva, C; Avalani, K; Havener, TM; Chirgwin, ME; Merten, E; Ong, HW; Willis, C; Abdelwaly, A; Helal, MA; Derbyshire, ER; Zutshi, R; Drewry, DH Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial  J Med Chem 65:13172-13197 (2022) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase 3
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
51607.56
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_749959
Residue:
440
Sequence:
MKNWPIDEDINIYEEKNHTNNKNYVNNFEMSDQKDEEEYSHSSNRSEDEDEERTIDNEINRSPNKSYKLGNIIGNGSFGVVYEAICIDTSEQVAIKKVLQDPQYKNRELMIMKNLNHINIIYLKDYYYTESFKKNEKNIFLNVVMEYIPQTVHKYMKYYSRNNQALPMFLVKLYSYQLCRALSYIHSKFICHRDLKPQNLLIDPRTHTLKLCDFGSAKNLLAGQRSVSYICSRFYRAPELMLGSTNYTTHIDLWSLGCIIAEMILGYPIFSGQSSVDQLVRIIQVLGTPTEDQLKEMNPNYADIKFPDVKSKDLRKVFPKGTPDEAINLITQFLKYEPLKRLNPIEALADPFFDELRDPCIKLPKYIDKLPELFNFCKEEIQEMSMECRRKIIPKNVYEEFLMVDENDNNIINDTISNDFNESNLDTNNSNNKTHVIIES
  
Inhibitor
Name:
BDBM50590015
Synonyms:
CHEMBL5207951
Type:
Small organic molecule
Emp. Form.:
C25H28ClN5OS
Mol. Mass.:
482.041
SMILES:
Cc1ccc(s1)-c1nc(Nc2ccc(cc2)C(=O)N2CCC(CC2)N2CCCC2)ncc1Cl
Structure:
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