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Target
Stimulator of interferon genes protein
Ligand
BDBM50590112
Substrate
n/a
Meas. Tech.
ChEMBL_2194970 (CHEMBL5107330)
EC50
13±n/a nM
Citation
 Vav?ina, Z; Perlíková, P; Milisavljevi?, N; Chevrier, F; Smola, M; Smith, J; Dejmek, M; Havlí?ek, V; Bud??ínský, M; Liboska, R; Vaneková, L; Brynda, J; Boura, E; ?ezá?ová, P; Hocek, M; Birku?, G Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. J Med Chem 65:14082-14103 (2022) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50590112
Synonyms:
CHEMBL5187347
Type:
Small organic molecule
Emp. Form.:
C33H33N9O13P2
Mol. Mass.:
825.6151
SMILES:
[H][C@@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@]([H])([C@@H]1O)[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)n1cc(-c2ccc(cc2)-c2ccccc2)c2c(N)ncnc12 |r|
Structure:
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