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Target
Beta-galactoside alpha-2,6-sialyltransferase 1
Ligand
BDBM50590208
Substrate
n/a
Meas. Tech.
ChEMBL_2195618 (CHEMBL5108134)
Ki
6000±n/a nM
Citation
 Dobie, C; Montgomery, AP; Szabo, R; Yu, H; Skropeta, D Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors. RSC Med Chem 12:1680-1689 (2021) [PubMed] 
Target
Name:
Beta-galactoside alpha-2,6-sialyltransferase 1
Synonyms:
Alpha 2,6-ST 1 | B-cell antigen CD75 | Beta-galactoside alpha-2,6-sialyltransferase 1 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 | ST6Gal I | ST6GalI | Sialyltransferase 1 | SIAT1_HUMAN | ST6GAL1 | SIAT1
Type:
PROTEIN
Mol. Mass.:
46622.19
Organism:
Human
Description:
ChEMBL_109837
Residue:
406
Sequence:
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC
  
Inhibitor
Name:
BDBM50590208
Synonyms:
CHEMBL5185498
Type:
Small organic molecule
Emp. Form.:
C25H23FN5Na2O10P
Mol. Mass.:
649.44
SMILES:
O[C@@H]1[C@@H](COCc2cn(nn2)C(c2ccc(F)c(Oc3ccccc3)c2)P([O-])([O-])=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
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