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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50090528
Substrate
n/a
Meas. Tech.
ChEMBL_303258 (CHEMBL826384)
Ki
44.7±n/a nM
Citation
 Holenz, J; Mercè, R; Díaz, JL; Guitart, X; Codony, X; Dordal, A; Romero, G; Torrens, A; Mas, J; Andaluz, B; Hernández, S; Monroy, X; Sánchez, E; Hernández, E; Pérez, R; Cubí, R; Sanfeliu, O; Buschmann, H Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. J Med Chem 48:1781-95 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50090528
Synonyms:
4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-benzenesulfonamide | 4-Amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide | 4-Amino-N-(2-methylamino-pyrimidin-4-yl)-benzenesulfonamide | 4-amino-N-(2,6-bis(methylamino)pyrimidin-4-yl)benzenesulfonamide | CHEMBL433461 | N-(2,6-bis(methylamino)pyrimidin-4-yl)-4-aminobenzenesulfonamide | Ro 04-6790 | Ro-04-6790
Type:
Small organic molecule
Emp. Form.:
C12H16N6O2S
Mol. Mass.:
308.359
SMILES:
CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1
Structure:
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