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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50590855
Substrate
n/a
Meas. Tech.
ChEMBL_2198504 (CHEMBL5111020)
Kd
5500±n/a nM
Citation
 Li, X; Craven, TW; Levine, PM Cyclic Peptide Screening Methods for Preclinical Drug Discovery. J Med Chem 65:11913-11926 (2022) [PubMed] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50590855
Synonyms:
CHEMBL5171791
Type:
Small organic molecule
Emp. Form.:
C31H37ClN6O5S2
Mol. Mass.:
673.246
SMILES:
CN1CCC(=O)NCCSCCS(=O)(=O)CCN(Cc2ccc(cc2)C#N)CC(=O)N[C@@H](Cc2cc3ccc(Cl)cc3[nH]2)C1=O |r|
Structure:
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