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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50591143
Substrate
n/a
Meas. Tech.
ChEMBL_2199455 (CHEMBL5111971)
IC50
5200±n/a nM
Citation
 Sainas, S; Giorgis, M; Circosta, P; Poli, G; Alberti, M; Passoni, A; Gaidano, V; Pippione, AC; Vitale, N; Bonanni, D; Rolando, B; Cignetti, A; Ramondetti, C; Lanno, A; Ferraris, DM; Canepa, B; Buccinną, B; Piccinini, M; Rizzi, M; Saglio, G; Al-Karadaghi, S; Boschi, D; Miggiano, R; Tuccinardi, T; Lolli, ML Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- J Med Chem 65:12701-12724 (2022) [PubMed] 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50591143
Synonyms:
CHEMBL5173387 | US20240034730, Compound 31
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4
Mol. Mass.:
417.4571
SMILES:
CC(C)Oc1cc(Oc2ccccc2)c(C)cc1NC(=O)c1c(O)nn2ccccc12
Structure:
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