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Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM50591310
Substrate
n/a
Meas. Tech.
ChEMBL_2199777 (CHEMBL5112293)
Ki
4346±n/a nM
Citation
 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101. J Med Chem 65:13946-13966 (2022) [PubMed] 
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA)
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM50591310
Synonyms:
CHEMBL5205289
Type:
Small organic molecule
Emp. Form.:
C19H24N2O7S
Mol. Mass.:
424.468
SMILES:
COc1cc(cc(OC)c1OCCC(N)C1COc2ccccc2O1)S(N)(=O)=O
Structure:
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