Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50165766
Substrate
n/a
Meas. Tech.
ChEMBL_302317 (CHEMBL828905)
Ki
46±n/a nM
Citation
Puccetti, L; Fasolis, G; Cecchi, A; Winum, JY; Gamberi, A; Montero, JL; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett 15:2359-64 (2005) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Inhibitor
Name:
BDBM50165766
Synonyms:
4-{4-[4-sulfamoylphenethylamino(thioxo)methylamino]phenylsulfonamidomethyl}-1-benzenesulfonamide | CHEMBL196198
Type:
Small organic molecule
Emp. Form.:
C22H25N5O6S4
Mol. Mass.:
583.724
SMILES:
NS(=O)(=O)c1ccc(CCNC(=S)Nc2ccc(cc2)S(=O)(=O)NCc2ccc(cc2)S(N)(=O)=O)cc1