Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50593010
Substrate
n/a
Meas. Tech.
ChEMBL_2206745 (CHEMBL5119453)
IC50
5.1±n/a nM
Citation
 Wu, X; Sun, P; Chen, X; Hua, L; Cai, H; Liu, Z; Zhang, C; Liang, S; Chen, Y; Wu, D; Ou, Y; Hu, W; Yang, Z Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. J Med Chem 65:11985-12001 (2022) [PubMed] 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50593010
Synonyms:
CHEMBL5198758
Type:
Small organic molecule
Emp. Form.:
C15H21BCl2N2O5
Mol. Mass.:
391.055
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)c1cc(Cl)ccc1Cl)B(O)O |r|
Structure:
Search PDB for entries with ligand similarity: