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Target
N-terminal Xaa-Pro-Lys N-methyltransferase 1
Ligand
BDBM60981
Substrate
n/a
Meas. Tech.
ChEMBL_2207099 (CHEMBL5119807)
IC50
460±n/a nM
Citation
 Dong, G; Deng, Y; Yasgar, A; Yadav, R; Talley, D; Zakharov, AV; Jain, S; Rai, G; Noinaj, N; Simeonov, A; Huang, R Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J Med Chem 65:12334-12345 (2022) [PubMed] 
Target
Name:
N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms:
2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A
Type:
PROTEIN
Mol. Mass.:
25382.72
Organism:
Homo sapiens
Description:
ChEMBL_119192
Residue:
223
Sequence:
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
  
Inhibitor
Name:
BDBM60981
Synonyms:
(2,3-diphenyl-1,2,4-thiadiazol-5-ylidene)-methyl-amine;hydrobromide | CHEMBL161867 | MLS002153327 | N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5-imine;hydrobromide | SCH-202676 hydrobromide | SMR001230740 | cid_11957689
Type:
Small organic molecule
Emp. Form.:
C15H13N3S
Mol. Mass.:
267.349
SMILES:
C\N=c1/nc(-c2ccccc2)n(s1)-c1ccccc1
Structure:
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