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Target
Calcium-activated potassium channel subunit alpha-1
Ligand
BDBM50593373
Substrate
n/a
Meas. Tech.
ChEMBL_2208121 (CHEMBL5121070)
EC50
>30000±n/a nM
Citation
 Sharma, S; Lesiak, L; Aretz, CD; Du, Y; Kumar, S; Gautam, N; Alnouti, Y; Dhuria, NV; Chhonker, YS; Weaver, CD; Hopkins, CR Discovery, synthesis and biological characterization of a series of  RSC Med Chem 12:1366-1373 (2021) [PubMed] 
Target
Name:
Calcium-activated potassium channel subunit alpha-1
Synonyms:
Calcium-activated potassium channel alpha/beta 1 | KCMA1_HUMAN | KCNMA | KCNMA1 | Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | SLO
Type:
PROTEIN
Mol. Mass.:
137567.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_938830
Residue:
1236
Sequence:
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
  
Inhibitor
Name:
BDBM50593373
Synonyms:
CHEMBL5182581
Type:
Small organic molecule
Emp. Form.:
C16H17Cl2N3O4S
Mol. Mass.:
418.295
SMILES:
Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1
Structure:
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