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Target
Glutaminase liver isoform, mitochondrial
Ligand
BDBM50593582
Substrate
n/a
Meas. Tech.
ChEMBL_2209098 (CHEMBL5122047)
EC50
12900±n/a nM
Citation
 Carbone, D; Vestuto, V; Ferraro, MR; Ciaglia, T; Pecoraro, C; Sommella, E; Cascioferro, S; Salviati, E; Novi, S; Tecce, MF; Amodio, G; Iraci, N; Cirrincione, G; Campiglia, P; Diana, P; Bertamino, A; Parrino, B; Ostacolo, C Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification. Eur J Med Chem 234:0 (2022) [PubMed] 
Target
Name:
Glutaminase liver isoform, mitochondrial
Synonyms:
3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase
Type:
PROTEIN
Mol. Mass.:
66331.64
Organism:
Homo sapiens
Description:
ChEMBL_117753
Residue:
602
Sequence:
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
  
Inhibitor
Name:
BDBM50593582
Synonyms:
CHEMBL5179292
Type:
Small organic molecule
Emp. Form.:
C26H27BrFN5OS
Mol. Mass.:
556.493
SMILES:
Br.Fc1ccc2n(CCCCN3CCOCC3)cc(-c3nc(cs3)-c3c[nH]c4ncccc34)c2c1
Structure:
Search PDB for entries with ligand similarity: