Reaction Details Report a problem with these data
Target
Interleukin-1 beta
Ligand
BDBM50511879
Substrate
n/a
Meas. Tech.
ChEMBL_2209375 (CHEMBL5122324)
IC50
2100±n/a nM
Citation
 Chen, J; Tang, P; Wang, Y; Wang, J; Yang, C; Li, Y; Yang, G; Wu, F; Zhang, J; Ouyang, L Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development. J Med Chem 65:5184-5211 (2022) [PubMed] 
Target
Name:
Interleukin-1 beta
Synonyms:
IL-1 beta | IL1B_MOUSE | Il1b
Type:
PROTEIN
Mol. Mass.:
30914.59
Organism:
Mus musculus
Description:
ChEMBL_120580
Residue:
269
Sequence:
MATVPELNCEMPPFDSDENDLFFEVDGPQKMKGCFQTFDLGCPDESIQLQISQQHINKSFRQAVSLIVAVEKLWQLPVSFPWTFQDEDMSTFFSFIFEEEPILCDSWDDDDNLLVCDVPIRQLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMSFVQGEPSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFNKIEVKSKVEFESAEFPNWYISTSQAEHKPVFLGNNSGQDIIDFTMESVSS
  
Inhibitor
Name:
BDBM50511879
Synonyms:
CHEMBL4466553
Type:
Small organic molecule
Emp. Form.:
C24H29N3O4
Mol. Mass.:
423.5048
SMILES:
COc1cc(OC)c2c(c1)nc([nH]c2=O)-c1cc(C)c(OCCN2CCCC2)c(C)c1
Structure:
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