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Target
Protein mono-ADP-ribosyltransferase PARP15
Ligand
BDBM50594001
Substrate
n/a
Meas. Tech.
ChEMBL_2210612 (CHEMBL5123561)
IC50
600±n/a nM
Citation
 Nizi, MG; Maksimainen, MM; Murthy, S; Massari, S; Alaviuhkola, J; Lippok, BE; Sowa, ST; Galera-Prat, A; Prunskaite-Hyyryläinen, R; Lüscher, B; Korn, P; Lehtiö, L; Tabarrini, O Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP15
Synonyms:
(ARTD7 or PARP15) | (ARTD7 or PARP15, Y598L) | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 7 | ARTD7 | B-aggressive lymphoma protein 3 | BAL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD7 or PARP15, Y598L) | PAR15_HUMAN | PARP-15 | PARP15 | Poly [ADP-ribose] polymerase 15 | Synonyms=BAL3
Type:
n/a
Mol. Mass.:
74595.89
Organism:
Homo sapiens (Human)
Description:
Q460N3
Residue:
678
Sequence:
MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSRSMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGPLSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSWQIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSPLQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMKIGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHRDFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITVADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
  
Inhibitor
Name:
BDBM50594001
Synonyms:
CHEMBL5186481
Type:
Small organic molecule
Emp. Form.:
C14H11BrFNO2
Mol. Mass.:
324.145
SMILES:
NC(=O)c1ccc(OCc2cccc(Br)c2)cc1F
Structure:
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