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Target
Protein mono-ADP-ribosyltransferase PARP16
Ligand
BDBM50594010
Substrate
n/a
Meas. Tech.
ChEMBL_2210621 (CHEMBL5123570)
IC50
>10000±n/a nM
Citation
 Nizi, MG; Maksimainen, MM; Murthy, S; Massari, S; Alaviuhkola, J; Lippok, BE; Sowa, ST; Galera-Prat, A; Prunskaite-Hyyryläinen, R; Lüscher, B; Korn, P; Lehtiö, L; Tabarrini, O Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP16
Synonyms:
2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 15 | ARTD15 | C15orf30 | Mono [ADP-ribose] polymerase PARP16 | PAR16_HUMAN | PARP-16 | PARP16 | Poly [ADP-ribose] polymerase 16 | Synonyms=ARTD15
Type:
PROTEIN
Mol. Mass.:
36398.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117586
Residue:
322
Sequence:
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR
  
Inhibitor
Name:
BDBM50594010
Synonyms:
CHEMBL5200358
Type:
Small organic molecule
Emp. Form.:
C15H11FN2O3
Mol. Mass.:
286.2578
SMILES:
Fc1ccccc1COc1ccc2c(c1)c(=O)[nH][nH]c2=O
Structure:
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