Reaction Details Report a problem with these data
Target
2-Hydroxyacid oxidase 1
Ligand
BDBM50594018
Substrate
n/a
Meas. Tech.
ChEMBL_2210645 (CHEMBL5123594)
Ki
2300±n/a nM
Citation
 Moya-Garzon, MD; Rodriguez-Rodriguez, B; Martin-Higueras, C; Franco-Montalban, F; Fernandes, MX; Gomez-Vidal, JA; Pey, AL; Salido, E; Diaz-Gavilan, M New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM50594018
Synonyms:
CHEMBL5180187
Type:
Small organic molecule
Emp. Form.:
C31H31N3O8
Mol. Mass.:
573.5931
SMILES:
N.N.OC(=O)c1cc(ccc1O)-c1ccc(CN(Cc2ccc(o2)-c2ccc(O)c(c2)C(O)=O)Cc2ccccc2)o1
Structure:
Search PDB for entries with ligand similarity: