Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50594186
Substrate
n/a
Meas. Tech.
ChEMBL_2211258 (CHEMBL5124207)
Ki
1.4±n/a nM
Citation
 Gopalan, G; Palo-Nieto, C; Petersen, NN; Hallberg, M; Larhed, M Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds. Bioorg Med Chem 65:0 (2022) [PubMed] 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50594186
Synonyms:
CHEMBL5174659
Type:
Small organic molecule
Emp. Form.:
C21H21N5O4S3
Mol. Mass.:
503.618
SMILES:
CCCc1nc(c(s1)S(=O)(=O)NC(=O)OC)-c1ccc(Cn2ccnc2-c2nccs2)cc1
Structure:
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