Reaction Details Report a problem with these data
Target
Alpha-synuclein
Ligand
BDBM50594222
Substrate
n/a
Meas. Tech.
ChEMBL_2211422 (CHEMBL5124371)
IC50
3930±n/a nM
Citation
 Han, F; Jiang, B; Lü, MH; Wang, ZP; Liu, W; Zhang, YX; Xu, J Hybrids of polyphenolic acids and xanthone, the potential preventive and therapeutic effects on PD: Design, synthesis, in vitro anti-aggregation of ?-synuclein, and disaggregation against the existed ?-synuclein oligomer and fibril. Bioorg Med Chem 66:0 (2022) [PubMed] 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM50594222
Synonyms:
CHEMBL5176552
Type:
Small organic molecule
Emp. Form.:
C22H15NO5
Mol. Mass.:
373.3582
SMILES:
Oc1ccc(O)c(\C=C\C(=O)Nc2ccc3oc4ccccc4c(=O)c3c2)c1
Structure:
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