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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM589235
Substrate
n/a
Meas. Tech.
ChEMBL_2212111 (CHEMBL5125060)
IC50
400±n/a nM
Citation
 Liu, Z; Duan, Z; Zhang, D; Xiao, P; Zhang, T; Xu, H; Wang, CH; Rao, GW; Gan, J; Huang, Y; Yang, CG; Dong, Z Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors. J Med Chem 65:10638-10654 (2022) [PubMed] 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM589235
Synonyms:
US11555009, Compound 15 | US11555009, Compound 29
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2N2O3
Mol. Mass.:
377.221
SMILES:
Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(O)=O)c(Cl)c1
Structure:
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