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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Ligand
BDBM50434353
Substrate
n/a
Meas. Tech.
ChEMBL_2213897 (CHEMBL5127029)
IC50
11±n/a nM
Citation
 Haghighijoo, Z; Zamani, L; Moosavi, F; Emami, S Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review. Eur J Med Chem 227:0 (2022) [PubMed] 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Synonyms:
DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2
Type:
PROTEIN
Mol. Mass.:
66690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508025
Residue:
601
Sequence:
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
  
Inhibitor
Name:
BDBM50434353
Synonyms:
CHEMBL2386747 | US9446044, 72
Type:
Small organic molecule
Emp. Form.:
C17H11Cl2N5OS
Mol. Mass.:
404.273
SMILES:
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Structure:
Search PDB for entries with ligand similarity: