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Target
NEDD8-activating enzyme E1 catalytic subunit
Ligand
BDBM50285607
Substrate
n/a
Meas. Tech.
ChEMBL_2214838 (CHEMBL5127970)
IC50
4.0±n/a nM
Citation
 Liang, Q; Liu, M; Li, J; Tong, R; Hu, Y; Bai, L; Shi, J NAE modulators: A potential therapy for gastric carcinoma. Eur J Med Chem 231:0 (2022) [PubMed] 
Target
Name:
NEDD8-activating enzyme E1 catalytic subunit
Synonyms:
6.2.1.- | NEDD8-activating enzyme E1 catalytic subunit | NEDD8-activating enzyme E1C | UBA3 | UBA3_HUMAN | UBE1C | Ubiquitin-activating enzyme 3 | Ubiquitin-activating enzyme E1C | Ubiquitin-like modifier-activating enzyme 3
Type:
PROTEIN
Mol. Mass.:
51843.76
Organism:
Homo sapiens
Description:
ChEMBL_116863
Residue:
463
Sequence:
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
  
Inhibitor
Name:
BDBM50285607
Synonyms:
MLN-4924 | MLN-4924003 | Pevonedistat
Type:
Small organic molecule
Emp. Form.:
C21H25N5O4S
Mol. Mass.:
443.519
SMILES:
[H][C@]1(O)C[C@@]([H])(C[C@@]1([H])COS(N)(=O)=O)n1ccc2c(N[C@@]3([H])CCc4ccccc34)ncnc12 |r|
Structure:
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