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Target
NEDD8-activating enzyme E1 regulatory subunit
Ligand
BDBM50537681
Substrate
n/a
Meas. Tech.
ChEMBL_2214851 (CHEMBL5127983)
EC50
3560±n/a nM
Citation
 Liang, Q; Liu, M; Li, J; Tong, R; Hu, Y; Bai, L; Shi, J NAE modulators: A potential therapy for gastric carcinoma. Eur J Med Chem 231:0 (2022) [PubMed] 
Target
Name:
NEDD8-activating enzyme E1 regulatory subunit
Synonyms:
APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 | ULA1_HUMAN
Type:
PROTEIN
Mol. Mass.:
60233.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939705
Residue:
534
Sequence:
MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
  
Inhibitor
Name:
BDBM50537681
Synonyms:
CHEMBL4640167
Type:
Small organic molecule
Emp. Form.:
C20H19ClN6O3
Mol. Mass.:
426.856
SMILES:
COc1cc(Nc2nc(Nc3ccc4[nH]ccc4c3)nnc2Cl)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: