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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50169239
Substrate
n/a
Meas. Tech.
ChEMBL_306189 (CHEMBL830983)
IC50
130±n/a nM
Citation
 Shi, GQ; Dropinski, JF; McKeever, BM; Xu, S; Becker, JW; Berger, JP; MacNaul, KL; Elbrecht, A; Zhou, G; Doebber, TW; Wang, P; Chao, YS; Forrest, M; Heck, JV; Moller, DE; Jones, AB Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity. J Med Chem 48:4457-68 (2005) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50169239
Synonyms:
(S)-(3-Cyclopropylmethyl-2-oxo-5,7-dipropyl-2,3-dihydro-benzooxazol-6-yloxy)-(4-isopropyl-phenyl)-acetic acid | CHEMBL364274
Type:
Small organic molecule
Emp. Form.:
C28H35NO5
Mol. Mass.:
465.5812
SMILES:
CCCc1cc2n(CC3CC3)c(=O)oc2c(CCC)c1O[C@H](C(O)=O)c1ccc(cc1)C(C)C
Structure:
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