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Target
ADP-ribose glycohydrolase MACROD2
Ligand
BDBM50088433
Substrate
n/a
Meas. Tech.
ChEMBL_2215855 (CHEMBL5128987)
IC50
500000±n/a nM
Citation
 Sherrill, LM; Joya, EE; Walker, A; Roy, A; Alhammad, YM; Atobatele, M; Wazir, S; Abbas, G; Keane, P; Zhuo, J; Leung, AKL; Johnson, DK; Lehtiö, L; Fehr, AR; Ferraris, D Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain. Bioorg Med Chem 67:0 (2022) [PubMed] 
Target
Name:
ADP-ribose glycohydrolase MACROD2
Synonyms:
3.2.2.- | 3.5.1.- | ADP-ribose glycohydrolase MACROD2 | C20orf133 | MACD2_HUMAN | MACRO domain-containing protein 2 | MACROD2 | O-acetyl-ADP-ribose deacetylase MACROD2 | [Protein ADP-ribosylaspartate] hydrolase MACROD2 | [Protein ADP-ribosylglutamate] hydrolase MACROD2
Type:
PROTEIN
Mol. Mass.:
47383.93
Organism:
Homo sapiens
Description:
ChEMBL_117875
Residue:
425
Sequence:
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK
  
Inhibitor
Name:
BDBM50088433
Synonyms:
Dihydralazine
Type:
Small organic molecule
Emp. Form.:
C8H10N6
Mol. Mass.:
190.2052
SMILES:
NNc1nnc(NN)c2ccccc12
Structure:
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