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Target
Adenosine receptor A2a
Ligand
BDBM8392
Substrate
n/a
Meas. Tech.
ChEMBL_2216591 (CHEMBL5129723)
Kd
560±n/a nM
Citation
 Shepherd, C; Robinson, S; Berizzi, A; Thompson, LEJ; Bird, L; Culurgioni, S; Varzandeh, S; Rawlins, PB; Olsen, RHJ; Navratilova, IH Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments. ACS Med Chem Lett 13:1172-1181 (2022) [PubMed] 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM8392
Synonyms:
CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide | pyrazolo[3,4-b]pyridine analogue 34
Type:
Small organic molecule
Emp. Form.:
C14H11BrN4O2
Mol. Mass.:
347.167
SMILES:
Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccco1
Structure:
Search PDB for entries with ligand similarity: