Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50595723
Substrate
n/a
Meas. Tech.
ChEMBL_2217808 (CHEMBL5130940)
IC50
1.000000±n/a nM
Citation
 Rosse, G Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase. ACS Med Chem Lett 13:1550-1551 (2022) [PubMed] 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50595723
Synonyms:
CHEMBL5193387
Type:
Small organic molecule
Emp. Form.:
C13H26BN3O5
Mol. Mass.:
315.174
SMILES:
C[C@@H](N)C(=O)NC[C@@H]1CC[C@@H](CCB(O)O)C[C@]1(N)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: