Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50171820
Substrate
n/a
Meas. Tech.
ChEMBL_322388 (CHEMBL856252)
IC50
423.0±n/a nM
Citation
 Shen, DM; Zhang, F; Brady, EJ; Candelore, MR; Dallas-Yang, Q; Ding, VD; Dragovic, J; Feeney, WP; Jiang, G; McCann, PE; Mock, S; Qureshi, SA; Saperstein, R; Shen, X; Tamvakopoulos, C; Tong, X; Tota, LM; Wright, MJ; Yang, X; Zheng, S; Chapman, KT; Zhang, BB; Tata, JR; Parmee, ER Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists. Bioorg Med Chem Lett 15:4564-9 (2005) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50171820
Synonyms:
3-{4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1,3-diaza-spiro[4.5]dec-1-ylmethyl]-benzoylamino}-propionic acid | CHEMBL199013
Type:
Small organic molecule
Emp. Form.:
C29H35Cl2N3O4
Mol. Mass.:
560.512
SMILES:
CC(C)(C)C1CCC2(CN(C(=O)N2Cc2ccc(cc2)C(=O)NCCC(O)=O)c2cc(Cl)cc(Cl)c2)CC1 |(14.12,-8.74,;15.21,-9.83,;16.3,-10.92,;14.12,-10.92,;16.3,-8.74,;17.52,-7.05,;19.03,-7.99,;21.26,-7.69,;21.73,-6.25,;23.27,-6.25,;23.75,-7.69,;25.2,-8.18,;22.5,-8.6,;22.5,-10.14,;23.82,-10.9,;23.82,-12.44,;25.15,-13.21,;26.49,-12.44,;26.49,-10.9,;25.15,-10.14,;27.83,-13.21,;27.83,-14.74,;29.16,-12.44,;30.48,-13.21,;31.81,-12.44,;33.15,-13.21,;33.15,-14.74,;34.48,-12.43,;24.17,-5.01,;25.7,-5.17,;26.61,-3.92,;28.13,-4.08,;25.98,-2.52,;24.45,-2.36,;23.82,-.96,;23.55,-3.61,;19.96,-8.97,;18.51,-8.45,)|
Structure:
Search PDB for entries with ligand similarity: