Reaction Details Report a problem with these data
Target
Protein mono-ADP-ribosyltransferase PARP16
Ligand
BDBM50594267
Substrate
n/a
Meas. Tech.
ChEMBL_2222293 (CHEMBL5135627)
IC50
362±n/a nM
Citation
 Brusa, I; Sondo, E; Falchi, F; Pedemonte, N; Roberti, M; Cavalli, A Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives. J Med Chem 65:5212-5243 (2022) [PubMed] 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP16
Synonyms:
2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 15 | ARTD15 | C15orf30 | Mono [ADP-ribose] polymerase PARP16 | PAR16_HUMAN | PARP-16 | PARP16 | Poly [ADP-ribose] polymerase 16 | Synonyms=ARTD15
Type:
PROTEIN
Mol. Mass.:
36398.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117586
Residue:
322
Sequence:
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR
  
Inhibitor
Name:
BDBM50594267
Synonyms:
CHEMBL5189477
Type:
Small organic molecule
Emp. Form.:
C15H12Cl2N2O2
Mol. Mass.:
323.174
SMILES:
O[C@@H]1[C@@H](CNC(=O)c2cc(Cl)c(Cl)cc12)c1ccccn1 |r|
Structure:
Search PDB for entries with ligand similarity: