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Target
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Ligand
BDBM50144724
Substrate
n/a
Meas. Tech.
ChEMBL_321473 (CHEMBL880414)
IC50
54.0±n/a nM
Citation
 Hong, F; Hollenback, D; Singer, JW; Klein, P Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta. Bioorg Med Chem Lett 15:4703-7 (2005) [PubMed]  Article 
Target
Name:
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Synonyms:
1-acylglycerol-3-phosphate O-acyltransferase beta | AGPAT2 | PLCB_HUMAN
Type:
PROTEIN
Mol. Mass.:
30924.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321473
Residue:
278
Sequence:
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
  
Inhibitor
Name:
BDBM50144724
Synonyms:
6-(5-Chloro-2-methoxy-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine | CHEMBL306107
Type:
Small organic molecule
Emp. Form.:
C17H14Cl2N4O
Mol. Mass.:
361.225
SMILES:
COc1ccc(Cl)cc1-c1cc(Nc2ccc(Cl)cc2)nc(N)n1
Structure:
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