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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50173825
Substrate
n/a
Meas. Tech.
ChEMBL_321126 (CHEMBL884981)
pH
7.8±n/a
EC50
>100000±n/a nM
Comments
extracted
Citation
 Kaur, N; Lu, X; Gershengorn, MC; Jain, R Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2. J Med Chem 48:6162-5 (2005) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_RAT | Thyroliberin receptor | Trhr
Type:
PROTEIN
Mol. Mass.:
46618.79
Organism:
Rattus norvegicus
Description:
ChEMBL_303571
Residue:
412
Sequence:
MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
  
Inhibitor
Name:
BDBM50173825
Synonyms:
1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide | CHEMBL381666
Type:
Small organic molecule
Emp. Form.:
C19H28N6O4
Mol. Mass.:
404.4634
SMILES:
CC(C)c1ncc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: