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Target
N-formyl peptide receptor 2
Ligand
BDBM50597236
Substrate
n/a
Meas. Tech.
ChEMBL_2223194 (CHEMBL5136528)
EC50
1300±n/a nM
Citation
 Wurtz, NR; Johnson, JA; Viet, A; Shirude, PS; Baligar, V; Madduri, S; Cheney, DL; Park, H; Lupisella, JA; Hsu, MY; Abousleiman, M; Galella, MA; Aulakh, D; Dierks, EA; Garcia, RA; Ostrowski, J; Kick, EK; Wexler, RR Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists. ACS Med Chem Lett 13:943-948 (2022) [PubMed] 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM50597236
Synonyms:
CHEMBL5186339
Type:
Small organic molecule
Emp. Form.:
C18H16F2N4O2
Mol. Mass.:
358.342
SMILES:
COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc3ccccc3[nH]2)c(F)c1 |r|
Structure:
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