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Target
fMet-Leu-Phe receptor
Ligand
BDBM50559829
Substrate
n/a
Meas. Tech.
ChEMBL_2223195 (CHEMBL5136529)
EC50
400±n/a nM
Citation
 Wurtz, NR; Johnson, JA; Viet, A; Shirude, PS; Baligar, V; Madduri, S; Cheney, DL; Park, H; Lupisella, JA; Hsu, MY; Abousleiman, M; Galella, MA; Aulakh, D; Dierks, EA; Garcia, RA; Ostrowski, J; Kick, EK; Wexler, RR Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists. ACS Med Chem Lett 13:943-948 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50559829
Synonyms:
CHEMBL4784510
Type:
Small organic molecule
Emp. Form.:
C18H17F2N3O3
Mol. Mass.:
361.3427
SMILES:
COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2)c(F)c1 |r|
Structure:
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