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Target
Lysine-specific histone demethylase 2
Ligand
BDBM50597560
Substrate
n/a
Meas. Tech.
ChEMBL_2223614 (CHEMBL5136948)
Ki
>200000±n/a nM
Citation
 Niwa, H; Watanabe, C; Sato, S; Harada, T; Watanabe, H; Tabusa, R; Fukasawa, S; Shiobara, A; Hashimoto, T; Ohno, O; Nakamura, K; Tsuganezawa, K; Tanaka, A; Shirouzu, M; Honma, T; Matsuno, K; Umehara, T Structure-Activity Relationship and  ACS Med Chem Lett 13:1485-1492 (2022) [PubMed] 
Target
Name:
Lysine-specific histone demethylase 2
Synonyms:
AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2
Type:
PROTEIN
Mol. Mass.:
92112.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_992590
Residue:
822
Sequence:
MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTATCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSNGKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPETSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRAAATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
  
Inhibitor
Name:
BDBM50597560
Synonyms:
CHEMBL5194434
Type:
Small organic molecule
Emp. Form.:
C10H12FNO
Mol. Mass.:
181.2068
SMILES:
COc1ccc(cc1F)[C@H]1C[C@H]1N |r|
Structure:
Search PDB for entries with ligand similarity: