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Target
Pyruvate kinase PKM
Ligand
BDBM50140257
Substrate
n/a
Meas. Tech.
ChEMBL_2224233 (CHEMBL5137746)
Ki
3530±n/a nM
Citation
 Arora, S; Joshi, G; Chaturvedi, A; Heuser, M; Patil, S; Kumar, R A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. J Med Chem 65:1171-1205 (2022) [PubMed] 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2)
Type:
Protein
Mol. Mass.:
57944.31
Organism:
Homo sapiens (Human)
Description:
P14618
Residue:
531
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM50140257
Synonyms:
5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin) | 5,7-dihydroxy-8-methoxyflavone | CHEMBL16171 | WOGONIN
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: