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Target
Triosephosphate isomerase, glycosomal
Ligand
BDBM50597993
Substrate
n/a
Meas. Tech.
ChEMBL_2224920 (CHEMBL5138433)
IC50
1200±n/a nM
Citation
 Beltran-Hortelano, I; Alcolea, V; Font, M; Pérez-Silanes, S Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease. Bioorg Med Chem 58:0 (2022) [PubMed] 
Target
Name:
Triosephosphate isomerase, glycosomal
Synonyms:
TIM | TPIS_TRYCR | Triose-phosphate isomerase
Type:
PROTEIN
Mol. Mass.:
27334.70
Organism:
Trypanosoma cruzi
Description:
ChEMBL_596695
Residue:
251
Sequence:
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
  
Inhibitor
Name:
BDBM50597993
Synonyms:
ANETHOLTRITHION | Anethole Trithione | Anethole trithione | Anetholtrithion | OP-2113 | OP2113
Type:
Small organic molecule
Emp. Form.:
C10H8OS3
Mol. Mass.:
240.365
SMILES:
COc1ccc(cc1)-c1cc(=S)ss1
Structure:
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