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Target
Decaprenylphosphoryl-beta-D-ribose oxidase
Ligand
BDBM50517949
Substrate
n/a
Meas. Tech.
ChEMBL_2226074 (CHEMBL5139587)
IC50
5.3±n/a nM
Citation
 Fernandes, GFS; Thompson, AM; Castagnolo, D; Denny, WA; Dos Santos, JL Tuberculosis Drug Discovery: Challenges and New Horizons. J Med Chem 65:7489-7531 (2022) [PubMed] 
Target
Name:
Decaprenylphosphoryl-beta-D-ribose oxidase
Synonyms:
1.1.98.3 | DPRE1_MYCS2 | Decaprenyl-phosphoribose 2'-epimerase subunit 1 | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase subunit DprE1 | Decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1
Type:
PROTEIN
Mol. Mass.:
50379.59
Organism:
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Description:
ChEMBL_116787
Residue:
460
Sequence:
MSTTEFPTTTKRLMGWGRTAPTVASVLSTSDPEVIVRAVTRAAEEGGRGVIARGLGRSYGDNAQNGGGLVIDMPALNRIHSIDSGTRLVDVDAGVSLDQLMKAALPHGLWVPVLPGTRQVTVGGAIGCDIHGKNHHSAGSFGNHVRSMELLTANGEVRHLTPAGPDSDLFWATVGGNGLTGIILRATIEMTPTETAYFIADGDVTGSLDETIAFHSDGSEANYTYSSAWFDAISKPPKLGRAAISRGSLAKLDQLPSKLQKDPLKFDAPQLLTLPDIFPNGLANKFTFMPIGELWYRKSGTYRNKVQNLTQFYHPLDMFGEWNRAYGSAGFLQYQFVVPTEAVEEFKSIIVDIQRSGHYSFLNVFKLFGPGNQAPLSFPIPGWNVCVDFPIKAGLHEFVTELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRIDEWIRIRRSVDPDGVFASDMARRLQLL
  
Inhibitor
Name:
BDBM50517949
Synonyms:
CHEMBL4447540
Type:
Small organic molecule
Emp. Form.:
C15H12N4O4S2
Mol. Mass.:
376.41
SMILES:
CCOC(=O)NC(=O)c1ccsc1NC(=O)c1nc2cnccc2s1
Structure:
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