Target
5-hydroxytryptamine receptor 5A
Ligand
BDBM50175465
Substrate
n/a
Meas. Tech.
ChEMBL_326578 (CHEMBL863367)
Ki
>1±n/a nM
Citation
 Kling, ALange, UEMack, HBakker, MHDrescher, KUHornberger, WHutchins, CWMöller, AMüller, RSchmidt, MUnger, LWicke, KSchellhaas, KSteiner, G Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs. Bioorg Med Chem Lett 15:5567-73 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
  
Inhibitor
Name:
BDBM50175465
Synonyms:
7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-ethyl]-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one | CHEMBL198463
Type:
Small organic molecule
Emp. Form.:
C25H28N6OS
Mol. Mass.:
460.594
SMILES:
CN1CCc2c(C1)sc1ncn(CCN3CCN(CC3)c3ccnc4ccccc34)c(=O)c21
Structure:
Search PDB for entries with ligand similarity: