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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50121447
Substrate
n/a
Meas. Tech.
ChEMBL_321315 (CHEMBL881411)
IC50
4.1±n/a nM
Citation
 Millet, R; Urig, S; Jacob, J; Amtmann, E; Moulinoux, JP; Gromer, S; Becker, K; Davioud-Charvet, E Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors. J Med Chem 48:7024-39 (2005) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50121447
Synonyms:
5-Nitro-furan-2-carboxylic acid N'-(2-naphthalen-2-yl-acetyl)-hydrazide | 5-Nitro-furan-2-carboxylic acidN'-(2-naphthalen-2-yl-acetyl)-hydrazide | CHEMBL120147
Type:
Small organic molecule
Emp. Form.:
C17H13N3O5
Mol. Mass.:
339.3022
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)NNC(=O)Cc1ccc2ccccc2c1
Structure:
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