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Target
Melatonin receptor type 1B
Ligand
BDBM50598931
Substrate
n/a
Meas. Tech.
ChEMBL_2228636 (CHEMBL5142149)
Ki
2.2±n/a nM
Citation
 Somalo-Barranco, G; Serra, C; Lyons, D; Piggins, HD; Jockers, R; Llebaria, A Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors. J Med Chem 65:11229-11240 (2022) [PubMed] 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50598931
Synonyms:
CHEMBL5209359
Type:
Small organic molecule
Emp. Form.:
C28H31N3O6
Mol. Mass.:
505.5622
SMILES:
CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc34)cc(=O)oc2c1
Structure:
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