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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50176648
Substrate
n/a
Meas. Tech.
ChEMBL_327489 (CHEMBL861781)
EC50
16±n/a nM
Citation
 Lowe, DB; Bifulco, N; Bullock, WH; Claus, T; Coish, P; Dai, M; Dela Cruz, FE; Dickson, D; Fan, D; Hoover-Litty, H; Li, T; Ma, X; Mannelly, G; Monahan, MK; Muegge, I; O'Connor, S; Rodriguez, M; Shelekhin, T; Stolle, A; Sweet, L; Wang, M; Wang, Y; Zhang, C; Zhang, HJ; Zhang, M; Zhao, K; Zhao, Q; Zhu, J; Zhu, L; Tsutsumi, M Substituted indanylacetic acids as PPAR-alpha-gamma activators. Bioorg Med Chem Lett 16:297-301 (2005) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50176648
Synonyms:
2-(5-(2-(2-(4-butylphenyl)-5-methyloxazol-4-yl)ethoxy)-2,3-dihydro-1H-inden-1-yl)butanoic acid | CHEMBL369930
Type:
Small organic molecule
Emp. Form.:
C29H35NO4
Mol. Mass.:
461.5925
SMILES:
CCCCc1ccc(cc1)-c1nc(CCOc2ccc3C(CCc3c2)C(CC)C(O)=O)c(C)o1
Structure:
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