Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50177217
Substrate
n/a
Meas. Tech.
ChEMBL_332849 (CHEMBL859228)
IC50
>333000±n/a nM
Citation
 Majerz-Maniecka, K; Musiol, R; Nitek, W; Oleksyn, BJ; Mouscadet, JF; Le Bret, M; Polanski, J Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors. Bioorg Med Chem Lett 16:1005-9 (2006) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50177217
Synonyms:
2-methyl-5-nitrosoquinolin-8-ol | CHEMBL202318
Type:
Small organic molecule
Emp. Form.:
C10H8N2O2
Mol. Mass.:
188.1827
SMILES:
Cc1ccc2c(ccc(O)c2n1)N=O
Structure:
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