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Target
Integrase
Ligand
BDBM50177220
Substrate
n/a
Meas. Tech.
ChEMBL_332849 (CHEMBL859228)
IC50
230000±n/a nM
Citation
 Majerz-Maniecka, K; Musiol, R; Nitek, W; Oleksyn, BJ; Mouscadet, JF; Le Bret, M; Polanski, J Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors. Bioorg Med Chem Lett 16:1005-9 (2006) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50177220
Synonyms:
2-(3-chlorostyryl)quinoline-7-carboxylic acid | 2-[2-(3-chlorophenyl)vinyl]quinoline-7-carboxylic acid | CHEMBL202369
Type:
Small organic molecule
Emp. Form.:
C18H12ClNO2
Mol. Mass.:
309.746
SMILES:
OC(=O)c1ccc2ccc(\C=C\c3cccc(Cl)c3)nc2c1
Structure:
Search PDB for entries with ligand similarity: