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Target
D(3) dopamine receptor
Ligand
BDBM50177366
Substrate
n/a
Meas. Tech.
ChEMBL_329734 (CHEMBL864615)
Ki
9.7±n/a nM
Citation
 Chen, J; Ding, K; Levant, B; Wang, S Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorg Med Chem Lett 16:443-6 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50177366
Synonyms:
CHEMBL201110 | N-(trans-4-(2-(8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethyl)cyclohexyl)quinoline-6-carboxamide
Type:
Small organic molecule
Emp. Form.:
C31H38N4O2
Mol. Mass.:
498.659
SMILES:
COc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4ccc5ncccc5c4)CC3CCc2c1 |wU:15.18,wD:12.11,(15.03,2.68,;16.36,3.45,;17.7,2.68,;17.69,1.13,;19.02,.36,;20.37,1.13,;21.71,.35,;21.72,-1.19,;23.07,-1.97,;24.41,-1.18,;25.75,-1.94,;27.08,-1.16,;28.42,-1.92,;28.42,-3.46,;29.75,-4.23,;31.08,-3.46,;31.07,-1.91,;29.74,-1.14,;32.41,-4.22,;32.42,-5.76,;33.75,-6.53,;31.09,-6.53,;31.09,-8.07,;29.77,-8.84,;28.42,-8.07,;27.1,-8.84,;25.78,-8.08,;25.77,-6.54,;27.1,-5.77,;28.43,-6.54,;29.75,-5.76,;24.41,.38,;23.05,1.14,;23.05,2.7,;21.69,3.47,;20.36,2.68,;19.02,3.45,)|
Structure:
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